Researchers Publish Study Concluding an Increased Risk of Death Among PPI Users

A team of researchers recently published a study where they found that proton pump inhibitors (PPI) may be tied to an increased risk of death.

The study recently published in the BMJ Open looked into the product commonly used to help patients who produce an excessive amount of acid stomach, and through their research the team discovered that it may be time to restrict the use of the product.

They found a connection between the use of PPIs and bone fractured in people with osteoporosis, C difficile infections, dementia and a heightened risk of developing chronic kidney disease or assisting the progression of chronic kidney disease.

“Although our results should not deter prescription and use of PPIs where medically indicated, they may be used to encourage and promote pharmacovigilance [monitoring the side-effects of licensed drugs] and [they] emphasise the need to exercise judicious use of PPIs and limit use and duration of therapy to instances where there is a clear medical indication and where benefit outweighs potential risk,” said the researchers in a news release.

The team used national US data gathered together from a network of healthcare systems that involved over six million people. The health of these people was tracked over a period of about six years, either until 2013 or until they passed away.

While there is no clear explanation for the findings, the consistency of the results and growing body of evidence is compelling, to say the least.

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