Oxbryta (generic name: voxelotor) was developed as a breakthrough treatment for sickle cell disease. Approved by the FDA in 2019, this medication offered hope for those suffering from the painful and life-threatening complications of this genetic blood disorder. However, growing reports of adverse side effects and serious complications have raised questions about Oxbryta's safety profile, prompting legal action across the country.
If you or a loved one suffered harm after taking Oxbryta, you may be entitled to compensation. The defective drug attorneys at Bailey Cowan Heckaman PLLC are investigating claims related to Oxbryta side effects and are ready to help you understand your legal options.
Contact us today for a free consultation.
What Is Oxbryta and How Is It Used?
Oxbryta is a prescription medication designed to treat sickle cell disease by improving hemoglobin levels. It works by inhibiting hemoglobin polymerization, a key process in the sickling of red blood cells. By preventing the distortion of red blood cells, Oxbryta helps improve oxygen delivery and reduce complications.
How Oxbryta Works
Voxelotor, the active ingredient in Oxbryta, binds to hemoglobin and increases its affinity for oxygen. This action is intended to reduce the formation of sickle-shaped cells, which can block blood flow and cause pain, anemia, organ damage, and strokes.
Who Typically Takes Oxbryta?
Oxbryta is approved for use in both adults and children aged 4 and older with sickle cell disease. It is often prescribed when other treatments, like hydroxyurea, are ineffective or produce intolerable side effects.
Sickle cell disease disproportionately affects the African American community. In the United States, approximately 1 in 365 African American births results in a child with sickle cell disease. The condition is also found in individuals of Hispanic, Middle Eastern, Indian, and Mediterranean descent, though to a lesser extent. Given the genetic nature of sickle cell disease, communities with a higher prevalence of the condition are at greater risk of being impacted by drugs like Oxbryta.
It’s critical that all patients, especially those in vulnerable and historically underserved communities, receive safe and effective treatment with full transparency about potential risks.
Oxbryta vs. Hydroxyurea
Hydroxyurea has long been a frontline treatment for sickle cell disease, reducing the frequency of painful episodes and the need for blood transfusions.
While hydroxyurea has been a mainstay treatment for decades, it can suppress bone marrow and cause fertility issues. Oxbryta presented a new approach, though it came with its own risks, now under increasing scrutiny.
Reported Oxbryta Side Effects and Complications
Since its release, patients and healthcare providers have reported a range of adverse effects linked to Oxbryta.
Common and Severe Side Effects
- Headache
- Diarrhea
- Abdominal pain
- Rash
- Fatigue
More severe and concerning reports have included:
- Liver toxicity
- Heart complications
- Worsening anemia
- Unexpected deaths in some patients
Oxbryta-Related Deaths and FDA Warnings
Though the FDA initially fast-tracked approval, ongoing monitoring has raised red flags. Reports of sudden patient deterioration and death, potentially linked to the medication, have fueled concerns about whether all risks were adequately disclosed during the approval process.
Has Oxbryta Been Recalled or Withdrawn from the Market?
As of now, Oxbryta has not been officially recalled by the FDA. However, its manufacturer, Global Blood Therapeutics (acquired by Pfizer), discontinued the drug’s marketing in some regions, citing regulatory and commercial reasons. This has led many to question whether safety concerns played a larger role. The FDA released a statement in 2024 stating that they were alerting “patients, caregivers, and health care professionals that Oxbryta (voxelotor) is being voluntarily withdrawn from the market by the manufacturer due to safety concerns.”
Are People Filing Oxbryta Lawsuits?
Yes, patients who experienced serious complications, or families of those who passed away, are turning to the courts for accountability.
Allegations Against Pfizer and Other Manufacturers
Lawsuits allege that the manufacturers failed to:
- Properly warn of the risks
- Conduct adequate safety testing
- Monitor and report post-market side effects
Failure to Warn and Pharmaceutical Liability
Drug makers have a legal obligation to warn doctors and patients of known risks. If a manufacturer fails to disclose serious side effects or minimizes their severity, they can be held legally responsible for the harm caused.
Your Legal Rights After Taking Oxbryta
If you or someone you love suffered severe complications while taking Oxbryta, you may qualify to file a lawsuit for damages.
Can You Sue for Oxbryta Injuries?
You may have grounds for a claim if:
- You were prescribed Oxbryta and suffered serious side effects
- Your injuries were not fully disclosed as potential risks
- A loved one passed away potentially due to the drug
What Compensation Might Be Available?
Successful claimants may recover compensation for:
- Medical expenses
- Lost wages
- Pain and suffering
- Funeral or burial costs (in wrongful death cases)
Why Choose Bailey Cowan Heckaman PLLC for Your Case?
At Bailey Cowan Heckaman PLLC, we have a proven track record of fighting large pharmaceutical companies on behalf of injured clients. We understand the complexities of defective drug litigation and have secured millions in verdicts and settlements for victims nationwide.
Our Track Record
Our firm has handled high-profile cases involving dangerous drugs and medical devices. We bring the experience and resources needed to take on big corporations—and win.
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Past Verdicts and Settlements
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Contact Us Today for a Free Case Evaluation
If you or a loved one was harmed by Oxbryta, don't wait to get help. Contact Bailey Cowan Heckaman PLLC today for a free consultation. We’ll review your case and help you understand your rights and options.
Call (713) 425-7100 or fill out our online form. There’s no fee unless we win your case.
